Professor Rick Payne (Jay Mohr), a professor at Rockland University specializing in myths, the paranormal, and the occult that helps Melinda in crossing ghosts over. He studies signs of the unknown. He is an intelligent yet arrogant professor. He seems to talk a lot about food in the episode "Love Never Dies". He is expected to become a regular character in season three.
Andrea Marino (Aisha Tyler), Melinda's best friend when she moves to Grandview who eventually learns of Melinda's gift (which Melinda told her about because she knows Andrea is not judgmental), and becomes business partners with Melinda in managing the antique store, "Same As It Never Was" before dying in the aforementioned plane crash. She was tempted to go with Romano in the Dark Side but Melinda crosses her over in to the Light.
Ned Banks (Tyler Patrick Jones), the son of Delia Banks aware of Melinda's gift before his mother.
Gabriel Rance (Ignacio Serricchio), a Ghost Whisperer who conspires with unnamed forces from the dark side to keep earthbound spirits, and orchestrate the destructive events to fufill the disastrous prophecy.
Romano AKA the Man in the Hat (John Walcutt), an evil spirit that keeps earthbound spirits, and during his physical lifetime, was an occult leader that was responsible for hundreds of suicides including his own. This character is likely to return in Season 3.
Homer the Dog, the ghost dog of Jim and Melinda that protects their house from evil spirits, first introduced in the episode Lost Boys.
